Fluorescence In Situ Hybridisation (FISH) is a gold-standard technique in cytogenetics, enabling genetic researchers and clinical labs to detect chromosomal abnormalities with high precision. However, manual FISH signal counting is often time-consuming, prone to human error, and physically demanding.

With MetaSystems’ Customisation Package Spot Counting, laboratories can now automate FISH analysis, reducing errors and significantly improving workflow efficiency. This cutting-edge technology seamlessly integrates with laboratory information management systems (LIMS) and works with various DNA FISH probes, enabling a smooth transition to digital pathology.

Challenges of Traditional FISH Spot Counting:

• Time-consuming – Manual microscopy requires extensive focus and effort.
• Error-prone – Human fatigue leads to inconsistent results.
• Poor documentation – Lack of automated imaging makes reviewing past cases difficult.

For clinical cytogenetics labs, cancer research facilities, and molecular diagnostics, these challenges can slow down genetic testing and affect result accuracy.

Why Lab Automation is the Future of FISH Analysis

With the Customisation Package Spot Counting, MetaSystems provides a state-of-the-art automated imaging solution that ensures:
• High-throughput FISH imaging – Processes up to 800 slides per run.
• Accurate and consistent results – Reduces human errors and improves data integrity.
• RapidScore for expert review – AI-assisted analysis speeds up result verification.
• Seamless LIMS integration – Automates data transfer and case management.

The Power of RapidScore in Digital Cytogenetics

One of the biggest innovations in automated FISH analysis is RapidScore—a machine-learning-assisted expert review process. This technology enables cytogeneticists and molecular pathologists to:
• Quickly review FISH signal patterns using an interactive keyboard.
• Confirm or modify automated suggestions with a single keystroke.
• Blindly review cases for unbiased analysis.
• Generate visually comprehensive reports for patient records and research publications.

Integration Without Disrupting Your Workflow

Metafer’s Customisation Package Spot Counting integrates with existing FISH probe assays and works with a wide range of fluorescence microscopy platforms.
Key Benefits:
• Compatible with multiple hybridisation techniques (Dual Color Break Apart, Dual Fusion, etc.)
• Works with overnight hybridisation probes from MetaSystems Probe
• Enables automated scanning and AI-driven spot classification
• Supports remote job generation via LIMS connectivity
Unlike other AI-powered FISH analysis tools, Metafer does not require a complete overhaul of your lab’s processes. Instead, it enhances your current FISH workflow, making the transition to automated cytogenetics seamless.

So don’t let manual counting slow your research down. Upgrade to automated FISH imaging today!

Contact Dr Mark Perkins to schedule a demo and see how automation can revolutionise your cytogenetics lab.