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Description

Denaturing Gradient Gel Electrophoresis (DGGE) is an important technique used in the search for mutations and DNA polymorphisms critical in genetic disorders and cancers, and to understand genetic diversity among species. This flexible system can be fully customised to perform several different mutation detection techniques. The VS20WAVE-DGGE is a versatile single-unit solution for different single-base pair mutation detection methods.

Using the innovative vertical screw-clamp technology of the new VS20-WAVE system, the VS20WAVE-DGGE is fully equipped with temperature control unit, stirrer, and gradient mixer and casting accessories to perform specific mutation analysis applications. A powerful microprocessor-controlled PID temperature control unit enables various mutation detection techniques to be undertaken between ambient temperature and 70C, while the simple fourscrew design of the WAVE insert accelerates set up of denaturing PAGE gels. Accordingly, the new VS20-DGGE can be used to screen single-base pair changes in the following applications:

• Heteroduplex analysis (HA)
• Parallel Denaturing Gradient Gel Electrophoresis (DGGE)
• Constant Denaturing Gradient Gel Electrophoresis (CDGE)

Features:

• Maximum 96-sample throughput compatible with microplates and thermal cycler blocks
• Four-screw vertical clamping technology accelerates set up
• Large format 20x20cm glass plates for improved resolution
• 100ml gradient mixer, with valve-controlled 50ml reservoir and mixing chambers, makes two 1mm parallel denaturing gradient gels
• Microprocessor-controlled temperature control unit accurate to 0.02C