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Corning® Matrigel® Matrix
£334.60 – £856.20 (Excluding VAT at 20%)
Description
Corning extracellular matrices (ECMs) enable researchers to mimic in vivo environments for 2D and 3D cell culture applications.
Corning Matrigel matrix is a solubilized basement membrane preparation extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumour rich in extracellular matrix proteins, including Laminin (a major component), Collagen IV, heparin sulfate proteoglycans, entactin/nidogen, and a number of growth factors.
Unique Features
- Proven and trusted since 1985; most extensively referenced basement membrane matrix
- Wide selection of basement membranes; used in diverse applications, from cancer and stem cell research to neurobiology
- Manufactured under stringent quality control practices that exceed industry standards, ensuring protein consistency and superior product performance
- Rigorous validation for functionality
- Certified LDEV-free
Applications
Corning Matrigel matrix is effective for the attachment and differentiation of both normal and transformed anchorage-dependent epithelioid and other cell types. These include neurons, Sertoli cells, chick lens, vascular endothelial cells, and hepatocytes.
- Influencing gene expression in adult rat hepatocytes
- 3D culture in mouse and human mammary epithelial cells
- In vivo peripheral nerve regeneration
- Metabolism and toxicology studies
- The development of several types of tumour cell invasion assays
- The in vitro and in vivo study of angiogenesis
- In vivo propagation of human tumours in immunosuppressed mice
- The maintenance of human embryonic stem cells and induced pluripotent stem (hiPS) cells
- Neuronal differentiation of hiPS cells
Matrigel Matrix Quality Control Specifications
- Mouse colonies routinely screened for pathogens via mouse antibody production (MAP) testing
- LDEV-free EHS tumour
- Extensive PCR testing performed on a number of pathogens, including LDEV, ensuring strict control of raw materials used during manufacturing
- Tested and found negative for the presence of bacteria, fungi, and mycoplasma
- Protein concentrations determined by Lowry method
- Endotoxin units measured by Limulus Amoebocyte Lysate assay
- Gel stability tested for a period of 14 days at 37°C
- Biological activity determined for each lot using a neurite outgrowth assay; chick dorsal root ganglia, plated on a 1.0 mm layer of Corning Matrigel matrix, required to generate positive neurite outgrowth response after 48 hours without the addition of nerve growth factor
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