When it comes to mimicking human disease, traditional 2D cell culture and animal models are often inadequate and limited in their physiological relevance. Cells grown in 3D more closely mimic in vivo behavior in tissues and organs.
There have been several recently established disease models involving human induced pluripotent stem cell (hiPSC)-derived 3D organoid culture systems. These systems also enable the use of patient-derived cells to generate models that provide valuable insight into the mechanism and progression of many diseases. The permeable support system can also be used to study disease pathophysiology and is particularly well suited for growing organotypic models at the air-liquid-interface (ALI).
This seminar will discuss the following topics:
- Benefits of 3D versus traditional cell culture technologies as disease models
- Use of hiPSC-derived 3D organoid and/or permeable support culture systems to create disease-specific tissue/organ models e.g. brain, liver, pancreas, intestinal, lung, skin, retina